Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients with Bipolar Depression
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate whether the changes in the fractional anisotropy (FA) of the UF tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric fields (EFs) in an association between FA of the UF and symptoms of anhedonia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:
• diagnosis of Bipolar Disorder and clinically significant anhedonia
• mild symptoms of depression
Locations
United States
Texas
The University of Texas Health Science Center at Houston
RECRUITING
Houston
Contact Information
Primary
Jair C Soares, MD,PhD
UTMoodDisorders@uth.tmc.edu
(713) 486-6663
Backup
Alexandre P Diaz, MD,PhD
UTMoodDisorders@uth.tmc.edu
(713) 486-6663
Time Frame
Start Date: 2022-10-06
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 45
Treatments
Experimental: active tDCS
Sham_comparator: sham tDCS
Related Therapeutic Areas
Sponsors
Leads: The University of Texas Health Science Center, Houston
Collaborators: Milken Institute